Every year in Ontario, smoking and alcohol consumption are responsible for thousands of deaths, hospitalizations, and emergency department visits. A new report by Ontario Health and Public Health Ontario provides estimates of the prevalence of smoking and alcohol use in the province and includes detailed estimates of the number of harms caused by smoking and alcohol consumption. The report also provides estimates of the number of cancer, cardiovascular, diabetes, respiratory, communicable disease, neuropsychiatric, and injury harms. These are provided for all of Ontario and for each public health unit.