In this presentation, Dr Chris Patriquin and Dr Monika Oliver review the diagnosis, treatment and management of Paroxysmal Nocturnal Haemoglobinuria (PNH). This very rare and debilitating disease of the bone marrow affects the blood and major organs. It is a chronic, life-threatening illness and can have devastating effects upon a patient physically, mentally and emotionally. This education video is designed to provide important information on paroxysmal nocturnal hemoglobinuria (PNH) signs, symptoms, and typical manifestations, including the CATCH criteria with a particular focus on thrombosis as a potential symptom.