I don't think anyone reads anything that's written here. But here's for the metadata: this video is explicitly about adrenergic receptors. More specifically, the Alpha subtype, and even more specifically, Alpha 2 Adrenergic Receptors. This thing throws a massive curveball to learners in all medical disciplines because Alpha 2 agonism / antagonism are opposite of Alpha 1. The topic of these receptors can be a few weeks long in a Pharm course in Medical and Pharmacy schools, and that course would be dedicated specifically to cardiac pharmacology, so this is as much I can cover in an 18 minute video. There might be people who will go "nooooo u cant just say that about my tree bark supplement" but the point is and has always been to teach about the pharmacology, its mechanism and how the setting of excess changes the pharmacokinetics-- the agent serves as a means for me to teach that because it has that activity. If it didn't have that activity, I'd talk about something else that does in this setting. It's a fascinating molecule, like all natural products. If you don't need to ingest it, don't ingest it, but I trust you are well in your best capacity to make decisions for yourself.