Antimicrobial resistance (AMR) has been declared one of the top 10 global public health threats facing humanity. The impacts of AMR can be mitigated through improved infection prevention and control, antimicrobial stewardship, innovation in treatment and prevention and surveillance. Given the critical importance of data in combating AMR, this presentation will discuss the findings from the Comprehensive Ontario Microbiology laBoratory Administrative daTa for AntiMicrobial Resistance (COMBAT-AMR) research program. This session will discuss the burden and impact of antimicrobial resistance on Ontario bloodstream and urinary tract infections.