Identification of leukocyte-lymphocyte ratio as a novel prognostic factor in Peripheral T-cell lymphoma

There is evidence of a link between breast cancer and thyroid disease. Patients with thyroid dysfunction have an increased incidence of breast cancer compared to healthy women. Therefore, the aim of this study was to evaluate the relevant prognostic value of nuclear and cytoplasmic thyroid receptor (TR) alpha expression and its α1 and α2 isoforms in breast cancer. TRα expression was found to play a contradictory role in BC prognosis depending on its intracellular localization: our results show that TRα and TRα2 expression play different prognostic roles depending on their subcellular localization. Cytoplasmic TRα was a negative prognosticator, whereas nuclear TRα2 expression was positively associated with overall survival. This study highlights the need to further investigate the behavior of TR depending on their intracellular localization. The significance of their subcellular expression and interaction with other members of the nuclear receptor family needs to be elucidated to find new treatment options for breast cancer in the future.

More than 60% of biliary tract cancer patients receive curative surgical resection. Nethereless, there is an absence of useful tools to predict prognosis before operation. Serum albumin and neutrophil-to-lymphocyte ratios are easily determined. Serum albumin is a marker of nutrition status and is correlated with prognosis in many cancer treatments. A neutrophil-to-lymphocyte ratio is a novel parameter widely used in most medical fields because it is a reliable marker of the immune response to different stimuli. Our study demonstrates that combined albumin and neutrophil scores, including nutritional and inflammatory indices, could predict operative survival in resectable biliary tract cancer patients.

Source：Holistic Integrative Oncology