In this Double Take video from the New England Journal of Medicine and NEJM Knowledge+, Jennifer Foreman (Randolph Health Medical Group) and her son, Dylan Glover, recount their journey through Dylan’s addiction and recovery. Ms. Foreman, along with Sarah Bagley (Boston Medical Center) and Scott Hadland (Massachusetts General Hospital for Children), reviews available medications for opioid use disorder and their mechanisms. They emphasize that multiple types of health care providers, including those in primary care, can manage and treat opioid use disorder. L.J. Punch (the T St. Louis, a harm-reduction program) also offers suggestions for harm reduction and guidance on how best to respond to an overdose.