This Double Take video from the New England Journal of Medicine presents the real-life case of a woman with progressive chest pain after a trip to Puerto Rico, where she spent time exploring local national parks and caves. Viewers are guided through the differential diagnosis of the patient’s presentation and how it evolves with the diagnostic evaluation, culminating in the patient’s final diagnosis and clinical course.

Some tobacco smokers use e-cigarettes to help them quit smoking, but the efficacy is unclear.

In this episode, Lisa Rosenbaum talks with physician trainees and a former residency program director to weigh the benefits and risks of the new wave of trainee unionization.

In this episode of the AI Grand Rounds podcast, Dr. James Zou shares his personal journey to discovering machine learning during his graduate studies at Harvard. Fascinated by the potential of AI and its application to genomics and medicine, Dr. Zou embarked on a journey that took him from journalism to the forefront of AI research. He has been instrumental at Stanford in translating machine learning advancements into clinical settings, particularly through genomics. The discussion also delves into the unique use of social media for gathering medical data, showcasing an innovative approach to AI model training with real-world medical discussions. Dr. Zou touches on the ethical implications of AI, the importance of responsible AI development, and the potential of language models like GPT-4 in medicine, despite the challenges of model drift and alignment with human preferences.

In this episode, Lisa Rosenbaum explores the shift in people’s perceptions of work’s role in our lives and its effects on medical training and the psychological satisfaction of physicians.

In Season 2 of the NEJM podcast “Not Otherwise Specified” (NOS), host Lisa Rosenbaum delves into multiple facets of a burgeoning revolution in medical training. In discussions with a diverse group of trainees, educators, and experts on evolving cultural norms, Lisa explores the effects of the Covid pandemic, societal changes in attitudes toward work, trainee unionization, clashes of generational philosophies, the well-being movement, and other key strands of the rapidly changing fabric of medical culture.

In the first podcast episode of NOS Season 2, “The Quiet Revolution in Medical Training,” host Lisa Rosenbaum talks with trainees, educators, and experts about the seeds of the current upheaval.

For patients with relapsing multiple sclerosis, inhibition of CD40L with the monoclonal antibody frexalimab may be a viable therapeutic strategy.

In this episode, a medical educator goes on the record with widespread but rarely publicly voiced concerns about the slippery slope from “wellness days” to inadequate medical training.

Highlighting gaps in communication near the end of life, this podcast episode explores a new approach to preparing patients with serious illness and their families for all possible outcomes.

Currently, no pharmacotherapies are approved for nonalcoholic steatohepatitis. Resmetirom is an oral, liver-directed, THR-β–selective agonist in development for NASH.

This Double Take video from the New England Journal of Medicine presents the case of a man with acute onset of nausea, vomiting, abdominal pain, fever, and hemoptysis. Based on a Clinical Problem-Solving article published in the Journal, the video explores the differential diagnosis based on the patient’s presenting symptoms and follows the evolution of the diagnosis as new findings arise from the diagnostic evaluation and the patient’s clinical course.

A single-dose vaccine that offers protection against all four dengue virus serotypes without regard to dengue baseline serostatus and across a wide age range is needed.

In the second half of our podcast series on historical injustices, guests Evelynn Hammonds and David Jones examine the racism of post-World War II American medicine and its lessons for the present day.

NEJM AI, a new monthly journal from NEJM Group, explores the cutting-edge applications of artificial intelligence and machine learning in clinical medicine. NEJM AI is an interdisciplinary journal facilitating dialogue among stakeholders invested in using AI to transform medicine. NEJM AI intentionally pairs “pre-clinical” and clinical articles to deliver critical context to both clinicians and non-clinician researchers. The journal bridges the fast-moving developments in AI, informatics, and technology in medicine with the application of these advancements to clinical practice. NEJM AI covers the application of AI methodologies and data science to biomedical informatics, connected health, telemedicine, medical images and imaging, personalized medicine, policy and regulation, and the ethical and medicolegal implications of AI.

NEJM Evidence, a new monthly digital journal from NEJM Group, presents innovative original research and fresh, bold ideas in clinical trial design and clinical decision-making. Learn what type of content you can expect from the editors of NEJM Evidence.

New multiple myeloma treatments are needed to attain long-term disease control. Adding the monoclonal antibody daratumumab to standard therapy has shown potential for improving outcomes.

In this Double Take video from the New England Journal of Medicine and NEJM Knowledge+, Jennifer Foreman (Randolph Health Medical Group) and her son, Dylan Glover, recount their journey through Dylan’s addiction and recovery. Ms. Foreman, along with Sarah Bagley (Boston Medical Center) and Scott Hadland (Massachusetts General Hospital for Children), reviews available medications for opioid use disorder and their mechanisms. They emphasize that multiple types of health care providers, including those in primary care, can manage and treat opioid use disorder. L.J. Punch (the T St. Louis, a harm-reduction program) also offers suggestions for harm reduction and guidance on how best to respond to an overdose.

Testosterone therapy improves bone density in men with hypogonadism, but large trials of long duration are needed to assess the effects of treatment on the incidence of fractures.

Over its 200-plus years, the Journal has sometimes published articles that have perpetuated injustices against various groups of people. A new Perspective series explores that history and its lessons.