NEJM AI, a new monthly journal from NEJM Group, explores the cutting-edge applications of artificial intelligence and machine learning in clinical medicine. NEJM AI is an interdisciplinary journal facilitating dialogue among stakeholders invested in using AI to transform medicine. NEJM AI intentionally pairs “pre-clinical” and clinical articles to deliver critical context to both clinicians and non-clinician researchers. The journal bridges the fast-moving developments in AI, informatics, and technology in medicine with the application of these advancements to clinical practice. NEJM AI covers the application of AI methodologies and data science to biomedical informatics, connected health, telemedicine, medical images and imaging, personalized medicine, policy and regulation, and the ethical and medicolegal implications of AI.