Development of fibrotic gene signature and construction of a prognostic model in melanoma

Thyroiditis is one of the most common immune toxicities in patients treated with combination immune checkpoint inhibition. Increased metabolic activity in the thyroid can be observed on FDG-PET/CT performed for the purposes of response assessment. The aim of our retrospective study was to assess the association and temporal profile of FDG-PET/CT findings suggesting thyroiditis with the natural history of clinical and biochemical thyroid dysfunction. Our findings demonstrated that an increased metabolic activity of the thyroid seen on routine FDG-PET/CT correlates with a biochemical diagnosis of thyroiditis and persists well after the initial biochemical diagnosis. We demonstrated that patients with FDG-PET/CT changes were more likely to develop overt clinical hypothyroidism.

In many brain disorders, neurocognitive impairment serves as a common denominator, manifesting as a decline in essential cognitive abilities and often signaling underlying brain pathology. Despite differences in etiology and progression, such brain disorders share underlying causes at the gene expression level. Gene expression data can be used to construct weighted gene co-expression networks to look for shared mechanisms across brain diseases. Identifying key genes within these networks could uncover a deeper understanding of such diseases and pave the way for the exploration of repurposed drugs.

作者：刘树伟 山东大学医学院