PHO Rounds - Leveraging Mucosal Immunology to Design Better Vaccines for Respiratory Viruses
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2023-10-18 17:51
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Parenteral vaccination (by injection) has been an important practice in preventing infectious diseases and can even be traced back to the early variolation practices for preventing smallpox. While parenteral vaccines have been extremely successful in reducing the burden of many infectious diseases, efficacy is often suboptimal against mucosal pathogens, which infects one or more mucosal tissues (for example, the respiratory mucosa, intestinal mucosa, vaginal mucosa, etc.). Advances in understanding of the unique properties of the mucosal immune system have catalyzed major innovations in the development of mucosal vaccines. These vaccines hold the promise of providing broad and durable protection against seasonal epidemics and future pandemics.
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